Beckman Coulter Centrifuges

Beckman Coulter Centrifuges

Beckman Coulter since 1947, from a world leader in general-purpose, high-performance centrifuges and ultracentrifuges that provide centrifugation solutions for laboratories, hospitals and universities around the world with superior quality, reproducibility and reliable performance. Innovative centrifugation technology has helped customers in life sciences, biotech, pharma, clinical diagnostics, academic and industrial sectors across the globe. Whether you are working on drug discovery, cell and tissue culture, blood banking, microplate processing, sample preparation and processing, or other clinical applications, reliably separating liquids based on density is essential. Looking for the perfect centrifuge to spin fluids or bring out suspended samples from a variety of mediums is essential. Beckman Coulter centrifuge portfolio ranges from the Microfuge line and larger, high-performance benchtop models to floor-model ultracentrifuges, and analytical ultracentrifugation AUC instruments. With extensive line of centrifuge rotors is also available for your specific application area, and designed to accommodate a variety of sample volumes, g-forces and RPMs. Beckman Coulter centrifuges are Malaysian Medical Device Authority (MDA) registered centrifuge.

Designed for Life Science & industrial application, Beckman Coulter benchtop centrifuges are a critical component of virtually any lab’s workflow. Each lab should have a centrifuge with reliability, durability, and precision with every spin. For common cell culture or tissue culture processing, from assays or grow cells in a plate format, processing tissue homogenates such as transfection or transduction, differential pelleting of harvesting cells or producing crude subcellular fractions from tissue homogenate. To Immunotherapy and gene therapy, nuclei and DNA extraction through cell lysis, debris clearing, nucleic acid precipitation, nucleic acid isolation or purification all by using aerosolve canister. So too for blood banking preparation, blood sample separations of red blood cells erythrocytes , white blood cells, platelets, and plasma. hematocrit test using microhematocrit. For virus Identification, antibody analysis or vaccine and therapy development, purification or isolation of viral vector plasmid such as Lentiviral Vector. With knowledge of Stokes equation, radial force and relative centrifugal force, and choosing the right centrifuge’s fixed angle rotors, swinging bucket rotors, horizontal rotors and vertical rotors, combine with method of configuration such as differential centrifugation, differential pelleting, rate-zonal centrifugation, isopycnic separation, also called buoyant separation or equilibrium separation and density gradient centrifugation, many wonder works can be obtained. For example, differential centrifugation with sedimentation pellet separated from the supernatant, common as pelleting subcellular organelles, DNA, viruses, bacteria, mitochondria, chloroplasts, yeast cells or algae and preparation of carbon nanotubes with centrifugal ultrafiltration membrane devices. Photothermal therapy, with tumor imaging, and metal-enhanced fluorescence using density gradient centrifugation to separate gold nanoparticles from wanted gold nanorods from gold nanospheres.

High-speed centrifuges are versatile tools for simple pelleting to rate zonal, elutriation and continuous flow separations . Equiped with the exclusive high-torque, switched reluctance (SR) drive shortens cycle times. Accelerate sample processing min 21,000 RMP with the maximum 110,510 g-force and simplified high throughput sample processing workflows to saving space and overcoming shared lab challenges, our versatile Avanti series of high-speed centrifuges are uniquely designed for your production needs. Centrifuge can be used at any proteomics laboratory for protein purification and protein aggregation qualification using various proteomics applications such as cell pelleting or cell harvesting for harvest and lyse, protein precipitation such as lysate clarification and crude purification, subcellular and membrane isolation using spin columns and density gradients or continuous rate zonal centrifuge for purified proteins or protein concentration.

Beckman coulter ultracentrifuges have a history of over 70 years were known affectionately as “Spincos” and constantly delivered first leading edge technology, since first developing the Model E, the world’s first analytical ultracentrifuge in 1947. From first floor-type preparative ultracentrifuge in 1949, first vacuum encased induction drive, first table-top ultracentrifuge and first electric non-chlorofluorocarbon (CFC) thermoelectric heating and cooling system. Accompany with first titanium rotor, top-loading swing rotor and near-vertical rotor. Ultracentrifugation has been a classic important application in disease control for harvesting of virus or virus preparation or virus purification in density gradients from cell culture medium to preparation of viruses for Electron Microscopy, to more exotic applications like the quantification of viruses. Modern applications include fetal bovine serum incorporated media to eliminate bovine exosomes from media. Use differential centrifugation for exosomes concentration or exosomes purification. Lentiviruses are commonly used viral vectors for genetic manipulation in mammalian cells. Another application would be concentration of lentiviral particles using sucrose cushion or Phosphate Buffered Saline. The Labware such as OptiSeal Tubes, QuickSeal Tubes, g-MAX System and Konical Tubes was designed to optimizing performance, ease of use, and safety for application for vaccine strain preparation such as nucleic acid RNA/DNA, Protein (mAb) and multi-antigen.

Beckman Coulter analytical ultracentrifugation is the most versatile, rigorous and accurate means for determining the molecular weight, hydrodynamic and thermodynamic properties of a protein or other macromolecule. It can be used to investigate nearly any type of molecule or particle over a wide range of concentrations and in a diverse variety of solvents. Currently, there is no other technique capable of providing the same range of information with a comparable level of precision and accuracy. In contrast to other methods used to analyze macromolecules, analytical ultracentrifugation (AUC) enables characterization of samples in their native state under biologically relevant solution conditions. AUC gives researchers two complementary views of solution behavior. Sedimentation velocity provides first-principle, hydrodynamic information about the size and shape of molecules. Sedimentation equilibrium provides the same type of information about the solution molar masses, stoichiometries, association constants and solution nonideality.