Beckman Coulter ultracentrifuges have been at the forefront of cutting-edge centrifugation technology for over 70 years. Affectionately known as “Spincos”, they have consistently delivered leading-edge advancements since the development of the Model E, the world’s first analytical ultracentrifuge, in 1947.

Milestones in ultracentrifuge innovation include:
✔ 1949 – First floor-type preparative ultracentrifuge
✔ First vacuum-encased induction drive
✔ First tabletop ultracentrifuge
✔ First electric, non-CFC (chlorofluorocarbon-free) thermoelectric heating & cooling system
✔ First titanium rotor, top-loading swing rotor, and near-vertical rotor

Ultracentrifugation in Disease Control & Research

Ultracentrifugation has been instrumental in disease control, particularly in virus harvesting, preparation, and purification using density gradients or sucrose gradients. It is widely used for:

✔ Virus purification from cell culture media
✔ Electron Microscopy sample preparation
✔ Virus quantification in research and diagnostics

Ultracentrifugation for Macromolecule Separation & Analysis

Ultracentrifugation is a powerful technique for the separation of organelles and subcellular components based on density and size. It is widely used for:

✔ Purification of macromolecules such as proteins, nucleic acids, and polysaccharides
✔ Analysis of macromolecular interactions (e.g., protein-protein and protein-DNA interactions)
✔ Determination of molecular weight, shape, and stoichiometry through sedimentation velocity and equilibrium analysis

Lipoprotein Fractionation & Cardiovascular Research

Ultracentrifugation is essential for studying lipid metabolism and assessing cardiovascular disease risk by:

✔ Separating lipoproteins such as chylomicrons based on density
✔ Fractionating lipoproteins for cholesterol and triglyceride analysis

Modern Applications: Exosomes & Lentiviral Particle Purification

✔ Exosome Isolation & Purification – Differential ultracentrifugation is used to concentrate or purify exosomes while eliminating bovine exosomes from fetal bovine serum (FBS)-supplemented media.
✔ Lentiviral Particle Concentration – Lentiviruses, widely used in gene therapy, are concentrated using sucrose cushions or phosphate-buffered saline (PBS). Their titer and purity can be analyzed using qPCR or ELISA.

Beckman Coulter Ultracentrifuge Models

Beckman Coulter offers state-of-the-art ultracentrifuge models to meet various research and industrial needs:

✔ Optima™ XPN – Premier ultracentrifuge with networking capabilities, customizable features, and multi-layered BioSafety features for a safe, productive work environment.
✔ Optima™ XE – Simplified, high-performance ultracentrifuge.
✔ Optima™ MAX-XP – Tabletop model with enhanced security and tracking features to ensure chain of custody and compliance.
✔ Optima™ MAX-TL – Compact tabletop ultracentrifuge for high-speed applications.
✔ Airfuge™ Air-Driven Ultracentrifuge – A rapid solution for removing chylomicrons (fat particles in lipemic samples) for accurate lipemic clarification.

Advanced Safety & Technology Features

Beckman Coulter ultracentrifuges are equipped with industry-leading safety and performance innovations, including:
✔ eXpert Simulation Software for optimized performance
✔ Vacuum-encased drive unit for durability
✔ Regenerative braking system for energy efficiency
✔ Magnetic sensor rotation monitoring for precise control
✔ Optical sensor overspeed disk for safety
✔ Dynamic rotor inertia check for reliability

High-Performance Labware for Vaccine & Biopharma Applications

Beckman Coulter’s labware is designed for optimal performance, ease of use, and safety, supporting applications in vaccine strain preparation, nucleic acid (RNA/DNA) extraction, protein (mAb) purification, and multi-antigen research.
✔ OptiSeal™ Tubes
✔ QuickSeal™ Tubes
✔ g-MAX™ System
✔ Konical™ Tubes

Regulatory Compliance

All Beckman Coulter centrifuges are registered with the Malaysian Medical Device Authority (MDA), ensuring compliance with global regulatory standards.