Beckman Coulter high-speed centrifuges are powerful tools that support a wide range of applications, from simple pelleting to advanced separation techniques for optimal results. These techniques include:

✔ Rate-Zonal Centrifugation – Separates particles based on size and shape.
✔ Elutriation – Separates particles based on size and density.
✔ Continuous Flow Separation – Similar to elutriation but designed for high-volume pelleting applications.

Enhanced Performance with Cutting-Edge Technology

Beckman Coulter high-speed centrifuges feature an exclusive high-torque, switched reluctance (SR) drive, which significantly reduces cycle times. With acceleration up to 21,000 RPM and a maximum g-force of 110,510, these centrifuges offer unparalleled efficiency.

Designed for high-throughput sample processing, they feature an ergonomic design that optimizes lab space utilization. Additionally, the MobileFuge remote application allows for easy monitoring and control, overcoming the challenges of shared lab environments.

Avanti Series – Optimized for Productivity and Safety

Beckman Coulter’s Avanti high-speed centrifuges are engineered for optimized production needs, featuring:

✔ Dynamic Rotor Inertia Check & Biosafe Safety Features – Prevents accidents and ensures user protection.
✔ Friction Reduction System (FRS) – A built-in system that reduces the rotor chamber pressure to one-fourth of atmospheric pressure, enhancing centrifuge reliability. By minimizing friction and drag, FRS:

• Reduces heat generation
• Increases centrifugal acceleration
• Enhances temperature control for better energy efficiency
• Lowers operational costs and extends the centrifuge’s lifespan

High-Speed Centrifugation in Proteomics & Bioprocessing

Beckman Coulter high-speed centrifuges are extensively used in proteomics laboratories for protein purification and aggregation qualification. The Avanti series, with its fixed-angle and large-volume processing rotors, supports various proteomics workflows, including:

Step-by-Step Protein Purification Process:

①Cell Pelleting (Cell Lysis) & Cell Harvesting – Initial step using low-speed rotors for sample collection. For higher volume processing, a continuous flow separation rotor is available.
②Protein Precipitation & Lysate Clarification – Efficient separation of proteins from non-protein components using high-speed, low-volume rotors.
③Crude Protein Purification – Recovery of bulk proteins from crude extracts using precipitants (e.g., ammonium sulfate, polyethylene glycol). This step requires medium-speed, fixed-angle rotors or benchtop centrifuges.
④Secondary Purification (Chromatography Columns) – Small-scale purification of recombinant proteins using a microcentrifuge for fast and simple processing.
⑤Tertiary Purification & Membrane Isolation – Subcellular fractionation (e.g., mitochondria, plasma membranes) using density gradients or rate-zonal centrifugation.
⑥Concentration & Buffer Exchange – Purification of proteins using ultracentrifugation, followed by buffer exchange via centrifugal concentrators with spin-column adapters.

Beyond Protein Purification – Applications in Nanotechnology & Industry

High-speed centrifugation extends beyond biological research into nanoparticle synthesis, biopharmaceuticals, food & beverage processing, and wastewater treatment.

✔ Nanoparticle Synthesis for Drug Delivery & Imaging

• Liposome Nanoparticles – Used in drug delivery systems.
• Gold & Iron Oxide Nanoparticles – Utilized for imaging and targeted drug applications.

✔ Industrial Applications

• Wastewater Treatment – Efficient separation of sludge, oil-water mixtures, and suspended solids.
• Food & Beverage Processing – Used for component separation in dairy and beverage production.

Available Beckman Coulter High-Speed Centrifuge Models

✔ Premier High-Speed Model: Avanti JXN Series – Advanced features for maximum performance.
✔ Simplified Model: Avanti J-E Series – Designed for ease of use and efficiency.
✔ High-Capacity Model: Avanti J-HC – Supports large sample volumes with Harvest Liners to minimize contamination and facilitate convenient sample recovery and storage.

All Beckman Coulter centrifuges are registered with the Malaysian Medical Device Authority (MDA), ensuring compliance with industry regulations.