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Beckman Coulter Particle Size Analyzers And Cell Counters, Sizers and Media Analyzers
Beckman Coulter Particle Size Analyzers And Cell Counters, Sizers and Media Analyzers
Beckman Coulter Life Sciences is a leader in scientific research instruments that primarily serve the academia and pharmaceutical markets. They also develop and manufacture solutions for the clinical research market and applied markets such as agricultural, food and beverage, gas and oil, aerospace, and several others.
Beckman Coulter LS13320XR Particle Size Analyzer are the most versatile and sophisticated laser diffraction particle sizing analyzer that offer the highest resolution, reproducibility and unsurpassed accuracy which help the user streamline workflows to optimize efficiency. With its availability of dry & liquid module, vast majority of the materials emulsion included can be measured in nanosizing or micro sizing by their size distribution profile. With the build in auto-modality, no prior knowledge of sample distribution needed. And by comparing with customer product’s goldern distribution curve created by their R & D department, the quality department can match with their daily output for quality monitoring.
Beckman Coulter Multisizer 4e Particle Sizer and Counter builds on the original proven technology Coulter Principle ISO 13319 with 9 approved ASTM methods & documented references has more than a century of experience on high resolution accurate counting and sizing particles and cells base on direct measurement of its volume not affected by the optical properties at concentration levels. Superior instrument designed with selection of aperture (Nominal Diameter, 10µm ~ 2000µm) thus measuring range of 0.2µm to 1600µm, from Liposome size of pharmaceutical; yeast & flavor emulsions for food & beverage; industrial powder of toner, abrasives & cosmetics; to biological sector such us algae, amoeba in marine biology, cell biology & micro biology of bacteria & mold. Improved sample management & dusty environments performance provides a great level of consistency for running the analyses. Combined with researcher-friendly, quality assurance-friendly intuitive software, a stream of multiple parameters that describe the entire pulse magnitudes that rise and fall as particles pass through the aperture are saved. This is practical tool to study volume changes associated to different process & time where particles could change during the length of the analysis for example in studies involving: Solubility, Crystal growth, Sample stability, Agglomeration, Bubble generation. The powerful and flexible software provides size and pulse data in numerous formats. A broad range of statistical parameters are automatically calculated and the results are presented in a customized report.
Beckman Coulter Cell Viability Analyzer And Bioanalyte Analyzer
Since the invention of the original COULTER COUNTER in 1954, COULTER COUNTER have built a full family of innovations that streamline cell counting, sizing, viability analysis and cell culture monitoring systems-thereby opening up new possibilities in life sciences.
Beckman Coulter Vi-CELL BLU Cell Viability Analyzer provides an automates the widely accepted trypan blue dye exclusion method for cell viability common in recombinant protein therapeutics by antibody & protein biopharmaceutical from various forms cell culture of microbial cell – baterial, yeasts, fungi, algae; plant cell – tobacco, soybean, alfalfa, tomato; insect cell from insect expression systems – baculovirus-insect, Insectselect, Dropophila expression; Mammalian cell – CHO, BHK, Mouse myeloma, Rat myeloma; human cell – HEK293, HT-1080, Huh-7, PER.C6; and stem cell stemcell therapy such as Hematopoietic stem cell – cord blood, bone marrow, peripheral blood; Mesenchymal stem cell – bone marrow, adipose tissue, tooth pulp. Cell viability historically been performed with a light microscope, pipette, and a hemacytometer which prone to have human error on variability and difficult to have reliability & repeatability. Beckman Coulter Vi-CELL BLU Cell Viability Analyzer provides results for percent viability, total cell & viable cell concentration and mean cell size with the advantages such as minimum variability, reliability, repeatability, easy workflow & fast result, maintenance free and most important is 21 CFR 11 Compliance ready.
Beckman Coulter Vi-CELL MetaFLEX Bioanalyte Analyzer measures the parameters most important in cell culture & whole blood: pH, Glucose, Lactate, pCO2, pO2, and electrolytes. With a sample as smallas 65µL & results in 35 second, it is ideal for micro to large scale analyzing mammalian/insect cell culture media and whole blood in research applications
ANATEL PAT700 Total Organic Carbon (TOC) Analyzers are specifically designed to fully comply with all global pharmacopeias (USP, EP, JP) requirements for TOC and conductivity for Purified Water and Water for Injection. Each sample is fully oxidized guaranteeing without using any chemicals but uses just powerful UV light. The most accurate TOC result that follows EP2.2.44 guidelines. With All 3 parameters, TOC, Uncompensated Conductivity and Temperaturecan be fully validated from just one analyzer, it can be fully calibrated and validated to USP<643> and USP<645>.
Auto Switching Dual UV Lamp For Yearly Service and Calibration Intervals. Excursion capture for root cause analysis support, Auto-sampler for sample automatically taken if there is a TOC excursion with built-in 4 bottle grab-sample analyzer for analyzing samples from other points in the water loop.
The ANATEL PAT700 discriminates between the inorganic carbon, which may be present in the water from sources such as dissolved CO2 gas and bicarbonate, and the CO2 generated from the oxidation of organic molecules in the sample. This discrimination is accomplished by measuring the inorganic carbon present before commencing to oxidize the organic carbon to CO2 and then subtracting it from the total carbon measurement made at the end of the oxidation process (total carbon is the sum of organic carbon and inorganic carbon).
Beckman Coulter ValitaTiter IgG Quantification Assay
Monoclonal antibodies (mAb) have established themselves as the leading biopharmaceutical therapeutic modality.
The accurate and reliable measurement of Immunoglobulin G (IgG) which is the major class of the five classes of immunoglobulins in human beings is essential in the development and subsequent manufacture to ensure optimal cell culture performance for the production of all biologics.
The ability to reliably monitor protein titer in real time throughout a bioprocess with an assay that enables accurate results with a minimal investment of time and resources allows operators to rapidly adjust the process conditions for maximum protein output while minimizing process time.
Beckman Coulter ValitaTiter and ValitaTiter Plus plates come precoated with a fluorescently-labeled derivative of protein G, IgG Fc-specific probe that the user reconstitutes prior to IgG test sample addition. The change in molecule size upon the binding of a fluorescently labeled Fc-specific probe can be detected using the degree of light depolarization in Fluorescence Polarization Microplate Reader.
The ValitaTiter assay range measures IgG concentrations from 2.5 to 100 mg/L or 100 mg/L to 2000 mg/L, with a simple add-and-read protocol. Analysis also can be carried out in crude cell culture media containing up to 10 x 106 cells/mL with a low sample volume and limited test sample pre-preparation.
