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Beckman Coulter Centrifuges
Beckman Coulter Centrifuges
Since 1947, Beckman Coulter has been a world leader in general-purpose, high-performance centrifuges and ultracentrifuges, delivering superior quality, reproducibility, and reliable performance to laboratories, hospitals, and universities worldwide.
Innovative Centrifugation Technology for Various Industries
Beckman Coulter’s cutting-edge centrifugation solutions support a wide range of industries, including:
✔ Life Sciences
✔ Biotech & Pharmaceutical Research
✔ Clinical Diagnostics
✔ Academic & Industrial Sectors
Whether you’re working in drug discovery, cell and tissue culture, blood banking, microplate processing, or clinical sample preparation, precise separation of liquids based on density is essential.
Comprehensive Centrifuge Portfolio
Beckman Coulter offers an extensive range of centrifuges, from compact microcentrifuges to high-performance benchtop models, floor-model ultracentrifuges, and analytical ultracentrifugation (AUC) instruments.
Additionally, an extensive line of centrifuge rotors is available, accommodating various sample volumes, g-forces, and RPMs to meet specific application needs.
Regulatory Compliance
Beckman Coulter centrifuges are registered with the Malaysian Medical Device Authority (MDA), ensuring compliance with industry standards.
Beckman Coulter Benchtop Centrifuges – Precision & Reliability for Life Science & Industrial Applications
Beckman Coulter benchtop centrifuges are essential tools in laboratories worldwide, providing unmatched reliability, durability, and precision for a variety of applications. From life sciences to industrial research, these centrifuges play a vital role in laboratory workflows.
Versatile Applications Across Multiple Fields
Cell & Tissue Culture Processing
✔ Common cell culture and tissue homogenization applications, including:
- Transfection or transduction
- Differential pelleting for harvesting cells
- Crude subcellular fractionation from tissue homogenates
Immunotherapy & Gene Therapy Research
✔ Nuclei and DNA extraction via cell lysis
✔ Debris clearing & nucleic acid precipitation
✔ Nucleic acid isolation & purification using aerosolve canisters
Blood Banking & Hematology
✔ Blood sample separation, isolating red blood cells (erythrocytes), white blood cells, platelets, and plasma
✔ Microhematocrit tests for hematocrit level analysis
Virology & Vaccine Development
✔ Virus identification & antibody analysis
✔ Vaccine and therapy development
✔ Purification and isolation of viral vector plasmids, such as Lentiviral Vectors
Advanced Centrifugation Techniques
With an understanding of Stokes’ equation, radial force, and relative centrifugal force (RCF), selecting the right centrifuge rotor and configuration method can unlock incredible possibilities:
🔹 Rotor Types:
- Fixed-angle rotors
- Swinging bucket rotors
- Horizontal rotors
- Vertical rotors
🔹 Centrifugation Methods:
- Differential centrifugation – separates sedimentation pellets from supernatant (used for organelles, DNA, viruses, bacteria, mitochondria, chloroplasts, yeast, algae, and even carbon nanotube preparation)
- Rate-zonal centrifugation – separates particles based on size and density
- Isopycnic separation (buoyant or equilibrium separation) – isolates components based on density
- Density gradient centrifugation – used in advanced applications, such as:
- Photothermal therapy (tumor imaging)
- Metal-enhanced fluorescence
- Separation of gold nanoparticles from nanorods and nanospheres
Beckman Coulter centrifuges combine scientific innovation and cutting-edge technology, delivering superior performance for research and industrial applications.
High-Speed Centrifuges – Advanced Separation for High-Throughput Workflows
High-speed centrifuges are versatile tools designed for a range of applications, from simple pelleting to rate-zonal, elutriation, and continuous flow separations.
Equipped with an exclusive high-torque, switched reluctance (SR) drive, these centrifuges shorten cycle times and optimize sample processing efficiency. With a maximum speed of 21,000 RPM and up to 110,510 g-force, the Avanti series of high-speed centrifuges are engineered to maximize throughput, save space, and overcome shared lab challenges—making them ideal for high-performance production workflows.
Ideal for Proteomics & Protein Research
High-speed centrifuges play a crucial role in proteomics laboratories, offering precise separation and purification for various protein-based applications, including:
✔ Cell pelleting & cell harvesting – For cell lysis and protein extraction
✔ Protein precipitation – Includes lysate clarification and crude purification
✔ Subcellular & membrane isolation – Using spin columns and density gradients
✔ Purified protein concentration – With continuous rate-zonal centrifugation
Designed to enhance efficiency and ensure reproducibility, these centrifuges are indispensable tools for protein purification, protein aggregation analysis, and high-throughput sample processing.
Beckman Coulter Ultracentrifuges – Pioneering Innovation for Over 70 Years
For more than 70 years, Beckman Coulter ultracentrifuges—affectionately known as “Spincos”—have been at the forefront of cutting-edge centrifugation technology. Since the introduction of the Model E, the world’s first analytical ultracentrifuge, in 1947, Beckman Coulter has continuously delivered groundbreaking advancements, including:
✔ First floor-type preparative ultracentrifuge (1949)
✔ First vacuum-encased induction drive
✔ First tabletop ultracentrifuge
✔ First electric non-CFC thermoelectric heating & cooling system
✔ First titanium rotor, top-loading swing rotor, and near-vertical rotor
Ultracentrifugation for Virology & Advanced Research
Ultracentrifugation has played a crucial role in disease control and virus research, with applications such as:
✔ Virus harvesting, preparation & purification using density gradients from cell culture media
✔ Preparation of viruses for Electron Microscopy (EM)
✔ Virus quantification for research & diagnostics
✔ Fetal bovine serum (FBS) media processing to eliminate bovine exosomes
✔ Exosome concentration & purification via differential centrifugation
✔ Lentiviral vector concentration for genetic manipulation in mammalian cells using a sucrose cushion or Phosphate Buffered Saline (PBS)
Optimized Labware for Precision & Safety
Beckman Coulter provides a range of high-performance labware to ensure efficiency, ease of use, and safety in applications such as vaccine strain preparation, including:
✔ OptiSeal Tubes
✔ QuickSeal Tubes
✔ g-MAX System
✔ Konical Tubes
These labware solutions are designed for applications involving RNA/DNA nucleic acid isolation, monoclonal antibody (mAb) purification, and multi-antigen vaccine development.
Beckman Coulter ultracentrifuges continue to redefine precision and innovation, making them an indispensable tool for modern laboratories.
Beckman Coulter Analytical Ultracentrifugation (AUC) – Precision in Macromolecular Analysis
Beckman Coulter’s analytical ultracentrifugation (AUC) is the most versatile, rigorous, and precise method for determining the molecular weight, hydrodynamic, and thermodynamic properties of proteins and other macromolecules.
Unmatched Versatility & Accuracy
AUC can be applied to a wide range of molecules and particles across various concentrations and solvent conditions, making it superior to any other technique in terms of precision and the breadth of information it provides. Unlike other macromolecule analysis methods, AUC allows for characterization in native states under biologically relevant conditions, ensuring results that closely reflect real-world behavior.
Two Complementary Analytical Approaches
AUC provides researchers with two powerful perspectives on solution behavior:
✔ Sedimentation Velocity (SV): Delivers first-principle hydrodynamic insights, revealing size and shape characteristics of molecules.
✔ Sedimentation Equilibrium (SE): Determines solution molar masses, stoichiometries, association constants, and solution non-ideality, offering a deeper understanding of molecular interactions.
By leveraging AUC, researchers can achieve unparalleled accuracy and insight into macromolecular properties, making it an indispensable tool for cutting-edge life sciences research.
